Pharmacodynamic effects of MTRX1011A administration in peripheral blood. Serum levels of soluble CD4-MTRX1011A complexes increased in a dose dependent fashion in the single dose phase (A) and multi-dose phase (B). MTRX1011A administration intravenously (IV) or subcutaneously (SC) lead to significant increase in CD69 expression on memory CD4 T cells in the single dose phase (C) and multi-dose phase (D).
Scheerens et al. Arthritis Research & Therapy 2011 13:R177 doi:10.1186/ar3502