Peripheral blood CD4 expression and CD4 occupancy. Mean changes in peripheral blood CD4 expression and CD4 occupancy on memory (CD45RA-) CD4 T cells in patients receiving placebo or MTRX1011A in the single dose (A and C) and multiple dose (B and D) phase of the study when administered intravenously (IV) or subcutaneously (SC) at doses ranging from 0.3 to 7 mg/kg. A and B, MTRX1011A treatment induced a dose dependent down modulation of CD4 expression on peripheral blood memory CD4 T cells. C and D, MTRX1011A administration resulted in a dose dependent occupancy of CD4 sites on peripheral blood memory CD4 T cells.
Scheerens et al. Arthritis Research & Therapy 2011 13:R177 doi:10.1186/ar3502