Table 3

Predictors of sRANKL, OPG and sRANKL/OPG ratio levels in SLE patients (after multivariate analysis)

Possible predictors

log(sRANKL)

log(OPG)

log(sRANKL/OPG ratio)


Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis§

Univariate analysis

Multivariate

analysis*

β coefficient (95% CI)

β coefficient

(95% CI)

β coefficient (95% CI)

β coefficient (95% CI)

β coefficient (95% CI)

β coefficient

(95% CI)

P-value

P-value

P-value

P-value

P-value

P-value

Age

-0.304

(-0.049 to -0.012)

-0.232

(-0.043 to -0.004)

0.218

(0.001 to 0.015)

-0.363

(-0.058 to -0.019)

-0.326

(-0.065 to -0.015)

0.002

0.017

0.027

< 0.001

0.001

BMI

-0.249

(-0.126 to -0.016)

-0.211

(-0.123 to -0.005)

0.011

0.033

Menopausal status

-0.210

(-1.131 to -0.006)

0.211

(0.003 to 0.439)

-0.274

(-1.379 to -0.200)

0.048

0.047

0.009

Lipid lowering therapy

-0.214

(-1.451 to -0.068)

0.032

Antihypertensive therapy

0.217

(0.026 to 0.438)

0.028

Diabetes mellitus

0.271

(0.198 to 1.122)

0.247

(0.117 to 0.984)

0.006

0.013

Triglycerides

0.266

(0.000 to 0.003)

0.306

(0.001 to 0.004)

0.011

0.02

Age at disease onset

-0.268

(-0.045 to -0.008)

0.237

(0.002 to 0.016)

-0.335

(-0.054 to -0.016)

0.006

0.016

0.001

Malar rash

0.251

(0.166 to 1.246)

0.243

(0.150 to 1.230)

0.201

(0.019 to 1.178)

0.011

0.013

0.043

Arthritis

-0.272

(-0.556 to -0.098)

0.005

Pleuritis

-0.197

(-1.555 to -0.010)

0.047

Anti-Sm titers

0.224

(0.003 to 0.051)

0.227

(0.005 to 0.051)

0.264

(0.009 to 0.059)

0.229

(0.006 to 0.053)

0.026

0.018

0.008

0.016

Anti-dsDNA titers

0.204

(0.000 to 0.007)

-0.208

(-0.003 to 0.000)

-0.239

(-0.004 to 0.000)

0.268

(0.001 to 0.009)

0.047

0.043

0.016

0.009


Multivariate analysis results from multiple linear regression analysis. The total explained variance of the model is (‡) R2 = 0.185, (§) R2 = 0.237, and (*) R2 = 0.175.

OPG, osteoprotegerin; SLE, Systemic Lupus Erythematosus; sRANKL, soluble RANKL

Carmona-Fernandes et al. Arthritis Research & Therapy 2011 13:R175   doi:10.1186/ar3500

Open Data