Table 3 |
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|
Predictors of sRANKL, OPG and sRANKL/OPG ratio levels in SLE patients (after multivariate analysis) |
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|
Possible predictors |
log(sRANKL) |
log(OPG) |
log(sRANKL/OPG ratio) |
|||
|
|
||||||
|
Univariate analysis |
Multivariate analysis‡ |
Univariate analysis |
Multivariate analysis§ |
Univariate analysis |
Multivariate analysis* |
|
|
β coefficient (95% CI) |
β coefficient (95% CI) |
β coefficient (95% CI) |
β coefficient (95% CI) |
β coefficient (95% CI) |
β coefficient (95% CI) |
|
|
P-value |
P-value |
P-value |
P-value |
P-value |
P-value |
|
|
Age |
-0.304 (-0.049 to -0.012) |
-0.232 (-0.043 to -0.004) |
0.218 (0.001 to 0.015) |
-0.363 (-0.058 to -0.019) |
-0.326 (-0.065 to -0.015) |
|
|
0.002 |
0.017 |
0.027 |
< 0.001 |
0.001 |
||
|
BMI |
-0.249 (-0.126 to -0.016) |
-0.211 (-0.123 to -0.005) |
||||
|
0.011 |
0.033 |
|||||
|
Menopausal status |
-0.210 (-1.131 to -0.006) |
0.211 (0.003 to 0.439) |
-0.274 (-1.379 to -0.200) |
|||
|
0.048 |
0.047 |
0.009 |
||||
|
Lipid lowering therapy |
-0.214 (-1.451 to -0.068) |
|||||
|
0.032 |
||||||
|
Antihypertensive therapy |
0.217 (0.026 to 0.438) 0.028 |
|||||
|
Diabetes mellitus |
0.271 (0.198 to 1.122) |
0.247 (0.117 to 0.984) |
||||
|
0.006 |
0.013 |
|||||
|
Triglycerides |
0.266 (0.000 to 0.003) |
0.306 (0.001 to 0.004) |
||||
|
0.011 |
0.02 |
|||||
|
Age at disease onset |
-0.268 (-0.045 to -0.008) |
0.237 (0.002 to 0.016) |
-0.335 (-0.054 to -0.016) |
|||
|
0.006 |
0.016 |
0.001 |
||||
|
Malar rash |
0.251 (0.166 to 1.246) |
0.243 (0.150 to 1.230) |
0.201 (0.019 to 1.178) |
|||
|
0.011 |
0.013 |
0.043 |
||||
|
Arthritis |
-0.272 (-0.556 to -0.098) |
|||||
|
0.005 |
||||||
|
Pleuritis |
-0.197 (-1.555 to -0.010) |
|||||
|
0.047 |
||||||
|
Anti-Sm titers |
0.224 (0.003 to 0.051) |
0.227 (0.005 to 0.051) |
0.264 (0.009 to 0.059) |
0.229 (0.006 to 0.053) |
||
|
0.026 |
0.018 |
0.008 |
0.016 |
|||
|
Anti-dsDNA titers |
0.204 (0.000 to 0.007) |
-0.208 (-0.003 to 0.000) |
-0.239 (-0.004 to 0.000) |
0.268 (0.001 to 0.009) |
||
|
0.047 |
0.043 |
0.016 |
0.009 |
|||
|
|
||||||
|
Multivariate analysis results from multiple linear regression analysis. The total explained variance of the model is (‡) R2 = 0.185, (§) R2 = 0.237, and (*) R2 = 0.175. OPG, osteoprotegerin; SLE, Systemic Lupus Erythematosus; sRANKL, soluble RANKL |
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|
Carmona-Fernandes et al. Arthritis Research & Therapy 2011 13:R175 doi:10.1186/ar3500 |
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