Table 5 |
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|
Correlations of clinical features with SSc associated autoantibodies |
||||||||||||||
|
ACA (310) |
ATA (260) |
Anti-PM-Scl (42) |
Anti-U1-RNP (41) |
Anti-RNA -P (33) |
Anti-Fibrillarin (12) |
Anti-Ku (10) |
Anti-Ro52 (187) |
Anti-Ro60 (59) |
Anti-La (16) |
AMA (41) |
Anti-p25/23 (28) |
ANA-negative (50) |
no SSc associated ab's (161) |
|
|
|
||||||||||||||
|
male sex 148 (17.1%) |
17 0.19 (0.11 to 0.32) P < 0.0001 |
64 2.02 (1.4 to 2.91) p = 0.0002 |
6 |
9 |
8 |
4 |
2 |
23 0.62 (0.38 to 0.997 p = 0.049 |
12 |
2 |
1 |
1 |
10 |
41 1.90 (1.261 to 2.863) p = 0,0035 |
|
age at disease onset < 50 y 399/781 (51.1%) |
115 0.57 (0.43 to 0.77) p = 0.0003 |
135 1.39 (1.02 to 1.88) p = 0.0431 |
22 |
29 2.92 (1.40 to 6.07) p = 0.0029 |
13 |
8 |
4 |
77 |
31 |
10 |
20 |
8 |
18 |
73 |
|
Rodnan skin score > 10 294/750 (39.2%) |
58 0.27 (0.19 to 0.38) P < 0.0001 |
132 3.10 (2.24 to 4.27) P < 0.0001 |
14 |
9 |
18 3.24 (1.44 to 7.31) p = 0.0042 |
7 |
1 |
58 |
23 |
6 |
10 |
11 |
14 |
56 |
|
Raynaud's phenomenon 819 (94.9%) |
301 2.26 (1.07 to 4.77) p = 0.0349 |
252 |
37 |
41 |
32 |
12 |
10 |
184 3.96 (1.2 to 12.94 p = 0.0133 |
58 |
16 |
41 |
28 |
43 0.29 (0.12 to 0.70) p = 0.0104 |
140 0.23 (0.12 to 0.42) P < 0.0001 |
|
Digital ulcers 216/840 (25.7%) |
55 0.50 (0.36 to 0.71) P < 0.0001 |
106 3.18 (2.30 to 4.41) P < 0.0001 |
9 |
11 |
7 |
4 |
1 |
48 |
19 |
6 |
13 |
6 |
4 0.26 (0.09 to 0.76) p = 0.0076 |
28 0.60 (0.39 to 0.94) p = 0.024 |
|
Pulmonary hypertension 126 (14.6%) |
57 1.58 (1.08 to 2.32) p = 0.0208 |
36 |
2 |
9 |
4 |
1 |
0 |
31 |
14 |
2 |
2 |
7 |
2 0.23 (0.06 to 0.97) p = 0.0232 |
17 |
|
Pulmonary fibrosis 287 (33.3%) |
39 0.18 (0.12 to 0.26) P < 0.0001 |
151 4.76 (3.48 to 6.50) P < 0.0001 |
16 |
11 |
7 |
2 |
6 |
69 |
30 2.20 (1.29 to 3.75 p = 0.0040 |
9 |
6 0.33 (0.14 to 0.79) p = 0.01 |
4 0.33 (0.11 to 0.95) p = 0.0393 |
11 |
55 |
|
Lung restrictive defect 218/833 (26.2%) |
41 0.31 (0.21 to 0.45) P < 0.0001 |
104 2.96 (2.14 to 4.09) P < 0.0001 |
9 |
7 |
8 |
3 |
4 |
45 |
19 |
4 |
8 |
4 |
10 |
34 |
|
Esophageal involvement 535 (62.0%) |
198 |
175 1.39 (1.02 to 1.89) p = 0.039 |
14 0.29 (0.152 to 0.56) p = 0.0001 |
29 |
20 |
7 |
6 |
120 |
39 |
13 |
24 |
21 |
27 |
87 0.67 (0.47 to 0.94) p = 0.0243 |
|
Proteinuria 90/830 (10.8%) |
23 0.56 (0.34 to 0.92) p = 0.0207 |
34 |
4 |
4 |
4 |
1 |
1 |
15 |
9 |
2 |
3 |
1 |
5 |
19 |
|
Cardiac involvement 114 (13.2%) |
27 0.51 (0.32 to 0.81) p = 0.0033 |
45 1.62 (1.08 to 2.44) p = 0.0216 |
5 |
7 |
5 |
1 |
2 |
20 |
9 |
1 |
4 |
1 |
5 |
22 |
|
Musculoskeletal involvement 421/852 (49.4%) |
131 0.64 (0.48 to 0.85) p = 0.0022 |
130 |
20 |
28 2.49 (1.25 to 4.96) p = 0.009 |
17 |
10 5.22 (1.14 to 23.97) p = 0.0202 |
6 |
80 0.71 (0.51 to 0.99) p = 0.0468 |
32 |
12 3.13 (1.002 to 9.79) p = 0.0447 |
17 |
9 |
25 |
79 |
|
Synovitis 157/837 (18.8%) |
35 0.43 (0.29 to 0.65) P < 0.0001 |
62 1.71 (1.19 to 2.45) p = 0.0049 |
8 |
13 2.27 (1.14 to 4.53) p = 0.0326 |
8 |
2 |
2 |
32 |
15 |
5 |
2 0.21 (0.05 to 0.89) p = 0.0216 |
2 |
10 |
29 |
|
Joint contractures 253/840 (30.1%) |
54 0.36 (0.25 to 0.50) P < 0.0001 |
107 2.26 (1.65 to 3.08) P < 0.0001 |
9 |
9 |
10 |
6 |
2 |
49 |
23 |
6 |
9 |
9 |
20 1.93 (1.05 to 3.54) p = 0.0436 |
56 |
|
Tendon friction rubs 88/840 (10.5%) |
14 0.30 (0.16 to 0.53) P < 0.0001 |
32 |
2 |
5 |
6 |
3 |
1 |
21 |
5 |
2 |
2 |
0 |
6 |
25 1.95 (1.18 to 3.22) p = 0.0122 |
|
CK elevation 74/835 (8.9%) |
14 0.37 (0.21 to 0.68) p = 0.0009 |
20 |
19 3.56 (1.67 to 7.57) p = 0.0023 |
5 |
6 2.60 (1.03 to 6.55) p = 0.0485 |
0 |
3 5.32 (1.30 to 21.72) p = 0.038 |
21 |
8 |
2 |
1 |
0 |
6 |
16 |
|
Sicca syndrome 366/858 (42.7%) |
150 1.44 (1.19 to 6.61) p = 0.0119 |
98 |
14 |
18 |
12 |
5 |
4 |
96 1.57 (1.13 to 2.17) p = 0.0075 |
33 1.85 (1.08 to 3.17) p = 0.0275 |
12 4.14 (1.32 to 12.93) p = 0.0102 |
19 |
20 3.50 (1.52 to 8.03) p = 0.0029 |
23 |
66 |
|
Mouth involvement 223/829 (26.9%) |
64 0.61 (0.44 to 0.85) p = 0.0034 |
93 2.1 (1.53 to 2.93) P < 0.0001 |
10 |
7 |
10 |
3 |
4 |
49 |
18 |
6 |
11 |
6 |
12 |
34 |
|
ESR > 25 mm/h 199/741 (26.9%) |
58 0.70 (0.49 to 0.99) p = 0.046 |
75 1.55 (1.10 to 2.19) p = 0.015 |
4 0.33 (0.11 to 0.94) p = 0.0325 |
14 |
5 |
0 |
0 |
60 1.76 (1.21 to 2.54) p = 0.0039 |
28 3.39 (1.92 to 5.97) P < 0.0001 |
9 3.62 (1.33 to 9.86) p = 0.0447 |
10 |
5 |
15 |
42 |
|
|
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|
ACA, anti-centromere antibodies; AMA, antimitochondrial antibodies; ANA, antinuclear antibodies; ATA, anti-topoisomerase I antibodies; CK, creatine kinase; ESR, erythrocyte sedimentation rate; RNAP = RNA polymerase; RNP = ribonucleoprotein; SSc, systemic sclerosis. Dichotomous variables are expressed as raw numbers, OR (95% CI) and P values. |
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|
Mierau et al. Arthritis Research & Therapy 2011 13:R172 doi:10.1186/ar3495 |
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