Production of IL-6 by peripheral monocytes stimulated with sBAFF. Monocytes (2.5 × 105/ml) prepared from normal individuals (closed circles) and primary Sjögren's syndrome (pSS) patients (open circles) were cultured for 96 hours in the presence of 0, 0.5, 1.0 and 2.0 μg/ml of recombinant human soluble B-cell-activating factor of the TNF family (sBAFF). The amounts of IL-6 in the culture supernatants were measured by sandwich ELISA. Data represent means ± SEM. **P < 0.01.
Yoshimoto et al. Arthritis Research & Therapy 2011 13:R170 doi:10.1186/ar3493