Table 3 |
||||
|
Most common rheumatoid arthritis patient-reported side effects to minocycline and doxycycline and their severity |
||||
|
Side effect |
Mild |
Moderate |
Severe |
Total (%) |
|
|
||||
|
Minocycline |
||||
|
Skin, other |
7 |
16 |
11 |
34 (25) |
|
Photosensitivity |
2 |
9 |
4 |
15 (11) |
|
Purpura |
2 |
10 |
1 |
13 (10) |
|
Dizziness |
8 |
2 |
3 |
13 (10) |
|
Rash |
0 |
3 |
5 |
8 (6) |
|
Nausea |
1 |
2 |
4 |
7 (5) |
|
Headache |
1 |
1 |
3 |
5 (4) |
|
Tinnitus |
3 |
1 |
0 |
4 (3) |
|
Diarrhea |
2 |
1 |
1 |
4 (3) |
|
Itching |
0 |
2 |
1 |
3 (2) |
|
Gastrointestinal, other |
0 |
2 |
1 |
3 (2) |
|
Abdominal pain |
1 |
1 |
1 |
3 (2) |
|
Other |
11 |
8 |
6 |
25 (18) |
|
Total (%) |
38 (28) |
58 (42) |
41 (30) |
137 (100) |
|
Doxycycline |
||||
|
Nausea |
3 |
10 |
4 |
17 (16) |
|
Skin, other |
7 |
2 |
2 |
11 (10) |
|
Photosensitivity |
2 |
4 |
3 |
9 (8) |
|
Dizziness |
6 |
2 |
1 |
9 (8) |
|
Rash |
0 |
5 |
3 |
8 (7) |
|
Abdominal pain |
0 |
5 |
2 |
7 (6) |
|
Purpura |
2 |
4 |
0 |
6 (6) |
|
Diarrhea |
2 |
2 |
2 |
6 (6) |
|
Itching |
0 |
3 |
0 |
3 (3) |
|
Tinnitus |
2 |
1 |
0 |
3 (3) |
|
Heartburn |
0 |
2 |
1 |
3 (3) |
|
Infections |
0 |
1 |
2 |
3 (3) |
|
Other |
7 |
12 |
6 |
25 (23) |
|
Total (%) |
31 (28) |
53 (48) |
26 (24) |
110 (100) |
|
|
||||
|
Smith et al. Arthritis Research & Therapy 2011 13:R168 doi:10.1186/ar3491 |
||||
