Open Access Research article

Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice

Facundo Las Heras12, Ralph S DaCosta38, Kenneth PH Pritzker24, Nigil Haroon15, George Netchev38, Hing Wo Tsui5, Basil Chiu5, W Mark Erwin69, Florence WL Tsui57* and Robert D Inman57*

Author Affiliations

1 Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada

2 Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada

3 Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

4 Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada

5 Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada

6 Division of Orthopaedic Surgery, University of Toronto, 100 College Street, Toronto, Ontario M5G 1L5, Canada

7 Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada

8 Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada

9 Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada

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Arthritis Research & Therapy 2011, 13:R163  doi:10.1186/ar3482

Published: 12 October 2011

Additional files

Additional file 1:

Radiographs comparing the sacroiliac joints (SIJ) from 8- and 12-week-old wild-type versus ank/ank mice. No ankylosis was detected.

Format: TIFF Size: 902KB Download file

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Additional file 2:

An old beagle spine with diffuse idiopathic skeletal hyperostosis (DISH). (a) A computed tomography (CT) micrograph showing contiguous bony fusion in the lumbar spine, connecting one vertebra to the next. (b) Histopathology of a typical osteophyte, which contains a contiguous bony fusion mass emanating from the vertebral body, complete with bone marrow (BM). A prominent feature in ank/ank spine (ill-defined connective tissue/fibrous tissue mass) is not observed in the old beagle spine.

Format: TIFF Size: 1MB Download file

Open Data