Table 2 |
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|
The prevalence of antibody to HCMVpp65 sub-fragments in patients with autoimmunity and healthy controls |
||||||
|
Antigens |
SLE |
SSc |
SS |
RA |
Normal |
|
|
|
||||||
|
Age (years) |
11 to 77 |
48 to 79 |
14 to 79 |
21 to 81 |
31 to 73 |
|
|
Mean (years) |
33.8 |
61.9 |
53.4 |
54.6 |
63.2 |
|
|
Total specimen |
61 |
20 |
13 |
50 |
45 |
|
|
Female (%) |
93.4 |
95 |
92.3 |
80 |
57.8 |
|
|
Responsiveness |
pp651 to 167 (%) |
4/61 (7) |
3/20 (15) |
5/13 (38) |
0/50 (0) |
6/45 (13) |
|
pp65167 to 336 (%) |
12/61 (20) |
5/20 (25) |
3/13 (23) |
16/50 (32) |
9/45 (20) |
|
|
pp65336 to 561 (%) |
37/61 (61) |
4/20 (20) |
2/13 (15) |
7/50 (14) |
2/45 (4) |
|
|
pp65336 to 379 (%) |
0/30 (0) |
|||||
|
pp65379 to 455 (%) |
22/30 (73) |
|||||
|
pp65455 to 561 (%) |
3/30 (10) |
|||||
|
pp65336 to 448 (%) |
17/22 (77) |
|||||
|
pp65336 to 439 (%) |
16/22 (73) |
|||||
|
pp65336 to 422 (%) |
9/22 (41) |
|||||
|
|
||||||
|
RA, rheumatoid arthritis; SS, Sjögren's syndrome; SSc, systemic sclerosis. For immunoblot and ELISA assay, detection of anti-pp65 sub-fragments antibody was tested with purified human cytomegalovirus (HCMV) virions, as described in materials and methods. The HCMV positivity is defined by mean + 3 s.e.m of normal control. The results are representative of triplicated experiments. |
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|
Hsieh et al. Arthritis Research & Therapy 2011 13:R162 doi:10.1186/ar3481 |
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