Table 6

Association between anticyclic citrullinated peptide antibody and rheumatoid factor with shared epitope alleles according to the du Montcel classification

aCCP

RF

Allele

OR (95% CI)

P value

OR (95% CI)

P value

S1 allele (n = 55)

2.9 (0.7 to 12.4)

0.2054

4.5 (1.2 to 16.9)

*0.0291

S2 allele (n = 28)

12.0 (2.4 to 59.5)

0.0019**

8.3 (1.6 to 43.3)

*0.0122

S3D allele (n = 38)

7.5 (1.8 to 31.4)

0.0100*

5.3 (1.3 to 22.7)

*0.0246

S3P allele (n = 61)

13.3 (3.2 to 54.4)

0.0003***

4.5 (1.2 to 16.8)

*0.0264

X allele (n = 64)

4.7 (1.2 to 17.6)

0.0213*

2.7 (0.8 to 9.8)

0.1678

aCCP = anticyclic citrullinated peptide antibodies; RF = rheumatoid factor. du Montcel classification is from du Montcel et al. [7]. OR (95% CI) and P values were calculated using Fisher's exact test to compare with SE noncarrier rheumatoid arthritis patients (n = 12). *P < 0.05. **P ≤ 0.001 and ***P ≤ 0.0003 values are highly significant.

Meyer et al. Arthritis Research & Therapy 2011 13:R160   doi:10.1186/ar3479