Table 5

Relationship between human leucocyte antigen-DRB1 shared epitope homozygosity or heterozygosity and risk of anticyclic citrullinated peptide antibody or rheumatoid factor seropositivity

Total cohort (n = 143)

Blacks (n = 124)

SS (n = 80)

SX (n = 52)

SS (n = 72)

SX (n = 43)

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

RF

7.0 (1.8 to 26.6)

0.0059

6.3 (1.5 to 25.7)

0.0126

4.5 (1.0 to 19.5)

0.0537

4.1 (0.9 to 19.3)

0.0813

aCCP

10.2 (2.6 to 40.3)

0.0010

9.2 (2.2 to 38.9)

0.0028

7.1 (1.6 to 30.4)

0.0121

6.4 (1.4 to 30.1)

0.0223

aCCP = anticyclic citrullinated peptide antibodies; HLA = human leucocyte antigen; RF = rheumatoid factor; SE = shared epitope; SS = homozygous for shared epitope allele; SX = heterozygous for shared epitope allele.

Meyer et al. Arthritis Research & Therapy 2011 13:R160   doi:10.1186/ar3479