Table 2 |
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Associations between traditional cardiovascular disease risk factors, IP related factors and insulin resistance after adjustment for age and gender |
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Variable |
Dependent variable † |
|
|
HOMA-IR (continuos) ▲ (β-Coefficient (95% CI)) |
IR* (HOMA-IR > 2.29)# (Odds ratio (95% CI)) |
|
|
|
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|
Age at time of study (per year) |
0.018 (-0.012, 0.048) |
1.02 (0.99, 1.04) |
|
Male gender |
0.044 (-0.665, 0.753) |
1.27 (0.67, 2.39) |
|
Current smoker |
0.004 (-0.747, 0.755) |
0.71 (0.37, 1.37) |
|
Obese (Y/N) |
1.602 (0.963, 2.240) |
4.02 (1.91, 8.50) |
|
SBP (per mmHg) |
0.029 (0.007, 0.050) |
1.02 (1.00, 1.04) |
|
DBP (per mmHg) |
0.043 (0.009, 0.077) |
1.04 (1.01, 1.08) |
|
TG (per mmol/L) |
1.057 (0.542, 1.572) |
3.95 (2.09, 7.46) |
|
T.Chol (per mmol/L) |
0.155 (-0.162, 0.472) |
1.19 (0.90, 1.59) |
|
HDL (per mmol/L) |
-1.375 (-2.172, -0.578) |
0.44 (0.21, 0.92) |
|
LDL (per mmol/L) |
0.193 (-0.169, 0.556) |
1.11 (0.80, 1.53) |
|
DM (On treatment for DM/DM/fasting glucose ≥ 7.1 mmol/L) |
-0.114 (-1.170, 0.942) |
0.73 (0.29, 1.82) |
|
IP disease duration (per month) |
-0.001 (-0.003, 0.001) |
1.00 (1.00, 1.00) |
|
RF positive |
0.924 (0.254, 1.594) |
2.20 (1.20, 4.06) |
|
ACPA positive |
1.051 (0.336, 1.767) |
3.00 (1.51, 5.96) |
|
ACR criteria for RA |
0.542 (-0.114, 1.198) |
1.62 (0.90, 2.93) |
|
Swollen joint (per joint) |
0.032 (-0.016, 0.080) |
1.03 (0.98, 1.07) |
|
Tender joint (per joint) |
0.029 (0.002, 0.056) |
1.01 (0.99, 1.04) |
|
CRP (per mg/L) |
0.007 (-0.012, 0.026) |
1.00 (0.99, 1.02) |
|
DAS28 |
0.168 (-0.100, 0.437) |
1.05 (0.83, 1.34) |
|
HAQ |
0.709 (0.237, 1.182) |
1.41 (0.91, 2.19) |
|
On steroids prior to baseline assessment |
-0.300 (-1.094, 0.493) |
0.74 (0.37, 1.48) |
|
On DMARDs prior to baseline assessment |
0.533 (-0.124, 1.190) |
1.31 (0.73, 2.34) |
|
On MTX prior to baseline assessment |
0.277 (-0.435, 0.989) |
0.94 (0.50, 1.76) |
|
On HQC prior to baseline assessment |
-0.218 (-1.636, 1.200) |
0.81 (0.24, 2.79) |
|
|
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▲Linear regression producing β-coefficients were used for continuous outcome. β-coefficients are considered statistically significant if their 95% CI values do not include zero. #Logistic regression producing odds ratios used for binary outcomes. Odds ratios are considered significant if the 95% CI values do not include 1. † (adjusted for age and gender) ACPA, anti-CCP antibody; ACR, American College of Rheumatology; BMI, body mass index; CRP, C-reactive protein; DAS, Disease Activity Score; DBP, diastolic blood pressure; DM, diabetes mellitus; DMARDs, disease modifying anti-rheumatic drugs; HAQ, Health Assessment Questionnaire; HCQ, hydroxychloroquine; HDL, high density lipoprotein; IP, inflammatory polyarthritis; LDL, low density lipoprotein; MTX, methotrexate; RF, rheumatoid factor; SBP, systolic blood pressure; T.Chol, total cholesterol; TG, triglycerides. |
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Mirjafari et al. Arthritis Research & Therapy 2011 13:R159 doi:10.1186/ar3476 |
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