Table 4 |
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|
Proportional hazards models for coronary outcomes using various measures of cholesterol, including only significant covariates in the models |
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|
Time-dependent covariate models |
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|
|
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|
Most recent TC |
Mean TC |
Time-adjusted mean TC |
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|
HR (95% CI) |
P |
HR (95% CI) |
P |
HR (95% CI) |
P |
|
|
Cholesterol (TC) |
1.86 (1.30, 2.68) |
0.001 |
2.07 (1.28, 3.36) |
0.003 |
2.07 (1.28, 3.34) |
0.003 |
|
Male sex |
1.90 (1.06, 3.41) |
0.03 |
1.83 (1.01, 3.29) |
0.046 |
1.82 (1.01, 3.29) |
0.047 |
|
Ageψ |
1.12 (1.07, 1.17) |
< 0.0001 |
1.13 (1.06, 1.20) |
< 0.0001 |
1.13 (1.06, 1.20) |
< 0.0001 |
|
SLEDAI-2K¶ |
1.09 (1.05, 1.13) |
< 0.0001 |
1.10 (1.06, 1.14) |
< 0.0001 |
1.10 (1.06, 1.14) |
< 0.0001 |
|
Corticosteroidsβ |
2.04 (1.20, 3.45) |
0.01 |
2.01 (1.19, 3.41) |
0.01 |
2.01 (1.19, 3.41) |
0.01 |
|
|
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|
95% CI, 95% confidence interval; AUC, area under the curve; BP, blood pressure (mm Hg); DBP: diastolic blood pressure (mm Hg); HR, hazard ratio; NS, not significant; P, P value; SBP, systolic blood pressure (mm Hg); TC, total plasma cholesterol (mmol/L). ψYears; age at the time of first available TC (or SBP or DBP) in time-constant models and coincident with each TC (or SBP or DBP) measurement in the time-dependent covariate models. ¶SLE Disease Activity Index 2000; scores range from 0 to 105, with higher scores indicating more-active disease; measured at the time of first available TC (or SBP or DBP) in time-constant models, and coincident with each TC (or SBP or DBP) measurement in the time-dependent covariate models. ¢Hypertension defined as diastolic BP ≥ 90 or systolic BP ≥ 140 mm Hg; defined as present ever during the study in time-constant models, and coincident with each TC measurement in the time-dependent covariate models. βCorticosteroids defined as used ever during the study in time-constant models, and coincident with each TC (or SBP or DBP) measurement in the time-dependent covariate models. ζElevated total plasma cholesterol (hypercholesterolemia) defined as total plasma cholesterol > 5.2 mmol/L; measured at the time of first available SBP or DBP in time-constant models, and coincident with each SBP or DBP measurement in the time-dependent covariate models. §Antimalarials include chloroquine and hydroxychloroquine; defined as used ever during the study in time-constant models, and coincident with each TC (or SBP or DBP) measurement in the time-dependent covariate models. ¥Immunosuppressives include methotrexate, azathioprine, mycophenolate mofetil, cyclosporine, and cyclophosphamide; defined as used ever during the study in time-constant models, and coincident with each TC (or SBP or DBP) measurement in the time-dependent covariate models. |
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|
Nikpour et al. Arthritis Research & Therapy 2011 13:R156 doi:10.1186/ar3473 |
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