Table 1

Statistical analysis of hRasGRP4 isoforms in healthy subjects and patients with RA and autoimmune controls

normal

variant (%)

OR

95% CI

P-value

Any variant

Healthy subjects

62

18 (22.5)

RA patients (total)

47

74 (67.3)

5.42

2.86 to 10.3

0.00000016

RA patients (untreated)

9

16 (64.0)

6.12

2.32 to 16.2

0.00029

Autoimmune controls

69

31 (31.0)

1.55

0.79 to 3.04

0.27

non-variant 6

variant 6

OR

95% C.I.

P-value

Variant 6

Healthy subjects

79

1 (1.3)

RA patients

95

20 (18.0)

16.6

2.18 to 126

0.00035

Autoimmune controls

92

8 (8.0)

6.87

0.84 to 56.1

0.038

CI, confidential interval and P-values were calculated by Chi-square test to evaluate the incidence of alternative splicing with healthy subjects and patients groups. The frequency of variant 6 in each group was evaluated by Fisher's exact probability test. The percentage (%) of sequenced clones that contained an aberrant hRasGRP4 transcript is also indicated. OR, odds ratio; RA, rheumatoid arthritis

Hashimoto et al. Arthritis Research & Therapy 2011 13:R154   doi:10.1186/ar3470