Effect of ONO-8815Ly on the expression of MMP-13 in femoral condyles. (a) Immunostaining for MMP-13 at two weeks after the operation. Sections of (a to e) medial and (f to j) lateral femoral condyles were prepared from samples of (a and f) G-S, (b and g) G-C, (c and h) G-0, (d and i) G-80, and (e and j) G-400. Magnification, 400×. Scale bar, 200 μm. Proportion of MMP-13-positive cells in (b) medial and (c) lateral femoral condyles at two weeks after the operation. Values are the mean ± standard deviation. *P < 0.05. MMP-13, matrix metalloproteinase-13; N.S, not significant.
Mitsui et al. Arthritis Research & Therapy 2011 13:R146 doi:10.1186/ar3460