Effect of CNP and dynamic compression on NO (a) and prostaglandin E2 (PGE2) release (b), [3H]-thymidine (c), and 35SO4 incorporation (d). Chondrocyte/agarose constructs were cultured with 0 or 10 ng/nl IL-1β and either 100 pM CNP or 100 nM CNP and/or 5 μM KT5823 for 48 hours (n = 8). (*), significant comparisons in unstrained and strained constructs for the multiple treatment conditions. All other comparisons (not indicated) were not significant.
Ramachandran et al. Arthritis Research & Therapy 2011 13:R145 doi:10.1186/ar3459