Figure 2.

Dose-response effect of high concentrations of CNP. Chondrocyte/agarose constructs were cultured under free-swelling conditions with 1 to 1000 nM CNP and 0 or 10 ng/nl IL-1β, and/or 5 μM KT5823 for 48 hours. (a) NO release; (b) prostaglandin E2 (PGE2) release; (c) [3H]-thymidine; and (d) 35SO4 incorporation (n = 6). (δ), significant comparisons for untreated versus CNP; (*), significant comparisons for IL-1β versus IL-1β + CNP; (+), significant comparisons for untreated versus IL-1β + CNP; (ψ), significant comparisons for IL-1β versus IL-1β + CNP + KT5823.

Ramachandran et al. Arthritis Research & Therapy 2011 13:R145   doi:10.1186/ar3459
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