Table 3

The comparative gene expression profiles of preclinical arthritis rats and Bhsp65-tolerized rats for the subsets of genes that play a role in the pathogenesis of arthritisa

Fold change (compared to baseline)

Gene symbol

Gene name

Preclinical arthritis rats

Bhsp65-tolerized rats


Costimulatory molecule

Cd86

CD86 molecule

#

+2.06*

Cytokine or cytokine receptor

Ifi47

Interferon γ-inducible protein 47

+2.44*

+2.37*

Ifi27l1

Interferon α-inducible protein 27-like 1

+2.14*

#

Il1a

Interleukin 1α

+4.61*

+3.21*

Il1b

Interleukin 1β

#

+3.05*

Lta

Lymphotoxin α (TNF superfamily, member 1)

#

+2.10*

Socs1

Suppressor of cytokine signaling 1

+3.67*

+3.14*

Socs3

Suppressor of cytokine signaling 3

#

+2.44*

Ifng

Interferon γ

+10.00*

+9.09*

Il12rb2

Interleukin 12 receptor β2

+4.08*

+3.89*

Il10

Interleukin 10

#

+2.07*

Il33

Interleukin 33

-2.50*

#

LOC301289

Similar to interleukin 17 precursor (IL-17)

+16.74*

#

Il17f

Interleukin 17F

+7.86*

#

RGD1561292

Interleukin 22

+7.26*

#

Chemokine/receptor

Cxcl10

Chemokine (C-X-C motif) ligand 10

+8.02*

+8.15*

Ccr5

Chemokine (C-C motif) receptor 5

+2.22*

+2.50*

Cxcr7

Chemokine (C-X-C motif) receptor 7

-2.47*

#

Angiogenesis

Wars

Tryptophanyl RNA synthetase

+2.29*

+2.17*

Vegfa

Vascular endothelial growth factor A

#

+2.21*

Nos2

Nitric oxide synthase 2, inducible

+7.83*

+4.77*

Others

Bst2

Bone marrow stromal cell antigen 2

+2.90*

+3.04*

Slc7a2

Solute carrier family 7 (cationic amino acid transport)

+4.98*

+4.15*


aBhsp65: mycobacterial heat shock protein 65. The genes listed were selected using false discovery rate < 5% and ≥2-fold change as the cutoff; +, upregulation; -, downregulation (- number); *significant compared to the corresponding baseline expression; #not significant compared to the corresponding baseline expression.

Yu et al. Arthritis Research & Therapy 2011 13:R143   doi:10.1186/ar3457

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