Table 1

The major functional groups represented by 322 differentially expressed genes at the incubation phase of adjuvant arthritis in Lewis ratsa

Functional group

Number (%)


Innate immunity

19 (5.9%)

Cell markers, innate immune response, complement

Cell-mediated adaptive immune response and effector functions

23 (7.1%)

Stress protein-related and other autoantigens, antigen processing and presentation, T cell costimulation,

cytokines and cytokine receptors, activators and regulators

Humoral immunity

8 (2.5%)

Cell proliferation

113 (35.1%)

DNA synthesis, replication, repair, tRNA processing, transcription, translation, cell

cycle and cellular components

Cell migration

24 (7.4%)

Adhesion molecules, integrins, chemokines and receptors, cell migration-related

Angiogenesis

2 (0.6%)

Oxygen metabolism related to pathogenesis of arthritis

11 (3.4%)

Transporters of oxygen, electrons, reactive oxygen species, cellular response to oxygen level and oxidation reduction

Articular damage

4 (1.2%)

Metabolism

25 (7.7%)

Glucose metabolism, proteolysis, peptide or amino acid transporter and protein metabolism, lipid metabolism and other metabolic processes

Signal transduction and signaling pathways

16 (5.0%)

Phosphorylation and dephosphorylation, kinase activity and regulation, signal

transduction and regulation, G protein-coupled receptor signaling pathway and others

Tumor- and disease-related

8 (2.5%)

Neuron development, neurotransmitters and neuropeptide signaling

4 (1.2%)

Ion binding and transporters, binding activity

7 (2.1%)

Undefined function and unnamed genes

59 (18.3%)


aDEG: differentially expressed gene; tRNA: transfer RNA. "Immune activity" group includes DEGs in the first three categories: 50 (15.5%).

Yu et al. Arthritis Research & Therapy 2011 13:R143   doi:10.1186/ar3457

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