Table 1 |
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The major functional groups represented by 322 differentially expressed genes at the incubation phase of adjuvant arthritis in Lewis ratsa |
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Functional group |
Number (%) |
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Innate immunity |
19 (5.9%) |
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Cell markers, innate immune response, complement |
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Cell-mediated adaptive immune response and effector functions |
23 (7.1%) |
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Stress protein-related and other autoantigens, antigen processing and presentation, T cell costimulation, cytokines and cytokine receptors, activators and regulators |
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Humoral immunity |
8 (2.5%) |
|
Cell proliferation |
113 (35.1%) |
|
DNA synthesis, replication, repair, tRNA processing, transcription, translation, cell cycle and cellular components |
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Cell migration |
24 (7.4%) |
|
Adhesion molecules, integrins, chemokines and receptors, cell migration-related |
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Angiogenesis |
2 (0.6%) |
|
Oxygen metabolism related to pathogenesis of arthritis |
11 (3.4%) |
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Transporters of oxygen, electrons, reactive oxygen species, cellular response to oxygen level and oxidation reduction |
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|
Articular damage |
4 (1.2%) |
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Metabolism |
25 (7.7%) |
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Glucose metabolism, proteolysis, peptide or amino acid transporter and protein metabolism, lipid metabolism and other metabolic processes |
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Signal transduction and signaling pathways |
16 (5.0%) |
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Phosphorylation and dephosphorylation, kinase activity and regulation, signal transduction and regulation, G protein-coupled receptor signaling pathway and others |
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Tumor- and disease-related |
8 (2.5%) |
|
Neuron development, neurotransmitters and neuropeptide signaling |
4 (1.2%) |
|
Ion binding and transporters, binding activity |
7 (2.1%) |
|
Undefined function and unnamed genes |
59 (18.3%) |
|
|
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aDEG: differentially expressed gene; tRNA: transfer RNA. "Immune activity" group includes DEGs in the first three categories: 50 (15.5%). |
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Yu et al. Arthritis Research & Therapy 2011 13:R143 doi:10.1186/ar3457 |
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