Table 1

Surface integrin levels of the predominant cell types in the rheumatoid arthritis synovium

α1

α2

α3

α4

α5

α6

αν

β1

β2

β3

β5


Synovial fibroblast

++

-

+(+)

-

+++

+

+++

+++

-

++

?

Macrophage

+

+

+

+++

+++

(+)

+++

+++

++

+++

+

Endothelium

++

+

++

+

+++

+

+++

+++

-

+++

+

T lymphocyte (Th1)

++

+

++

+++

+++

+

+++

+++

++

+++

+

Th17 cell

-

++

++

++

+++

+

+++

+++

++

?

?

B lymphocyte

++

+

++

+++

+++

+

++

+++

++

?

?


For most integrins, expression level data in the literature are given as 'high' or 'strong'. This makes it hard to estimate integrin levels on different cell populations. We consulted several publications and, albeit subjectively, categorized integrin expression levels on a range from strong to weak expression (indicated by one, two, or three plus signs). ?, There is no available data in the literature about the expression of respective integrins.

Lowin and Straub Arthritis Research & Therapy 2011 13:244   doi:10.1186/ar3464