Figure 4.

Characteristics of somatic hypermutation and generation of autoantibodies. AID, activation-induced cytidine deaminase; CDR, complementarity-determining region; Ig, immuonglobulin; RGYW, purine (R), guanine (G), pyrimidine (Y), adenine/thymine (W); S → R, silent-to-replacement; SHM, somatic hypermutation; WRCY, adenine/thymine (W), purine (R), cytosine (C), pyrimidine (Y).