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Highly Accessed Review

Lupus nephritis: current update

Ramesh Saxena*, Tina Mahajan and Chandra Mohan*

Author Affiliations

Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

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Arthritis Research & Therapy 2011, 13:240  doi:10.1186/ar3378

Published: 28 September 2011

Abstract

Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how the disease is currently diagnosed and treated.