Table 1

Animal models of arthritis

Model

Abbreviation

Species

Feature


Induced models

Non-specific immune stimuli

Adjuvant-induced arthritis

AA

Lewis rat

Autoimmune

Oil-induced arthritis

OIA

DA rat

Autoimmune

Pristane-induced arthritis

PIA

DA ra

Autoimmune

Cartilage directed autoimmunity

Collagen-induced arthritis

CIA

DBA mouse

CII AI

Proteoglycan-induced arthritis

PGIA

Balb/c mouse

PG AI

Infectious agents/exogenous triggers

Streptococcal cell wall arthritis

SCW-A

Lewis rat

Persistent bacteria AI

Flare

SCW-F

Mouse

Th17

Antigen-induced arthritis

AIA

Rabbit, mouse

Persistent antigen

Flare

AIA-F

Mouse

Th17

Transgenic spontaneous models

HTLV-induced arthritis

HTLV

Mouse

Viral tax antigen

KRN arthritis

KRN

K/BxN mouse

GPI AI

SKG arthritis

SKG

Mouse

ZAP-70 T cell defect

GP130 arthritis

GP130

Mouse

STAT3, T cell defect

TNF transgenic arthritis

TNFtg

Mouse

TNF overexpression

IL-1ra transgenic arthritis

IL-1ra-/-

Balb/c mouse

Autoimmune T cells

IL-1 transgenic arthritis

IL-1tg

Mouse

IL-1 overexpression

Immune complex models

Collagen type II

CAIA

DBA mouse

Mouse CII antibody

KRN serum

GPI

Balb/c mouse

Mouse GPI antibody

Poly-L-lysine-lysozyme

PLL-L

DBA mouse

Cationic antigen

New animal model

Spontaneous

Inherited inflamed joints strain

IIJ

Arthritic male mouse crossed with SJL/J females

Autoimmune arthritis (for understanding the female bias)


AI, autoimmunity; CII, collagen type II; GPI, glucose-6-phosphate isomerase; HTLV, human T-lymphotropic virus; IL, interleukin; KRN, C57Bl/6 mice carrying the KRN transgene heterozygously; PG, proteoglycan; SKG, SKG strain, derived from closed breeding colony of BALB/c mice, spontaneously develops chronic arthritis; TNF, tumor necrosis factor.

Cuzzocrea Arthritis Research & Therapy 2011 13:126   doi:10.1186/ar3434