Arthritis Research & Therapy | Volume 13 Issue 5

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	Volume 13 Issue 5
	Comment
	Editorial Characterization of a novel and spontaneous mouse model of inflammatory arthritis Salvatore Cuzzocrea Arthritis Research & Therapy 2011, 13:126 (16 September 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Fibroblast growth factor 2: good or bad guy in the joint? Tonia L Vincent Arthritis Research & Therapy 2011, 13:127 (30 September 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Bisphosphonates for osteoarthritis David A Walsh, Victoria Chapman Arthritis Research & Therapy 2011, 13:128 (30 September 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Use of administrative claims data for comparative effectiveness research of rheumatoid arthritis treatments Seo Kim, Daniel H Solomon Arthritis Research & Therapy 2011, 13:129 (7 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Declining needs for total joint replacements for rheumatoid arthritis Nasim A Khan, Tuulikki Sokka Arthritis Research & Therapy 2011, 13:130 (19 October 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Pus: the Rodney Dangerfield of immunology David S Pisetsky Arthritis Research & Therapy 2011, 13:131 (26 October 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis Xinhua Yu, Saleh M Ibrahim Arthritis Research & Therapy 2011, 13:132 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Dupuytren's: a systems biology disease Samrina Rehman, Royston Goodacre, Philip J Day, Ardeshir Bayat, Hans V Westerhoff Arthritis Research & Therapy 2011, 13:238 (12 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis Manon C Zweers, Tineke N de Boer, Joël van Roon, Johannes WJ Bijlsma, Floris PJG Lafeber, Simon C Mastbergen Arthritis Research & Therapy 2011, 13:239 (21 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Lupus nephritis: current update Ramesh Saxena, Tina Mahajan, Chandra Mohan Arthritis Research & Therapy 2011, 13:240 (28 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models Simanta Pathak, Chandra Mohan Arthritis Research & Therapy 2011, 13:241 (30 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Osteoimmunology and osteoporosis Piet Geusens, Willem F Lems Arthritis Research & Therapy 2011, 13:242 (30 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Mechanisms of B cell autoimmunity in SLE Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Integrins and their ligands in rheumatoid arthritis Torsten Lowin, Rainer H Straub Arthritis Research & Therapy 2011, 13:244 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus Travis Hughes, Amr H Sawalha Arthritis Research & Therapy 2011, 13:245 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research
	Research article Integrated safety in tocilizumab clinical trials Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines Yihong CS Lu, Christopher H Evans, Alan J Grodzinsky Arthritis Research & Therapy 2011, 13:R142 (2 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short term treatment of damaged cartilage with glucocorticoids can reduce long term degenerative changes; results from this in vitro study may offer hope for prevention of osteoarthritis after joint injury.
	Research article The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge Hua Yu, Changwan Lu, Ming T Tan, Kamal D Moudgil Arthritis Research & Therapy 2011, 13:R143 (13 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Ossification process involving the human thoracic ligamentum flavum: role of transcription factors Kenzo Uchida, Takafumi Yayama, Hong-Xin Cai, Hideaki Nakajima, Daisuke Sugita, Alexander Guerrero, Shigeru Kobayashi, Ai Yoshida, Ke-Bing Chen, Hisatoshi Baba Arthritis Research & Therapy 2011, 13:R144 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs Manoj Ramachandran, Prim Achan, Donald M Salter, Dan L Bader, Tina T Chowdhury Arthritis Research & Therapy 2011, 13:R145 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability Hiroto Mitsui, Tomoki Aoyama, Moritoshi Furu, Kinya Ito, Yonghui Jin, Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, Akio Nishiura, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Arthritis Research & Therapy 2011, 13:R146 (14 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Improved responsiveness and reduced sample size requirements of PROMIS physical function scales with item response theory James F Fries, Eswar Krishnan, Matthias Rose, Bharathi Lingala, Bonnie Bruce Arthritis Research & Therapy 2011, 13:R147 (14 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article A new category of autoinflammatory disease associated with NOD2 gene mutations Qingping Yao, Lan Zhou, Philip Cusumano, Nilanjana Bose, Melissa Piliang, Bijal Jayakar, Le-Chu Su, Bo Shen Arthritis Research & Therapy 2011, 13:R148 (14 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice Kaoru Yoshida, Akira Ochiai, Hiroaki Matsuno, Gabriel S Panayi, Valerie M Corrigall Arthritis Research & Therapy 2011, 13:R149 (14 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium Jolien Suurmond, Annemarie L Dorjée, Mariëtte R Boon, Edward F Knol, Tom WJ Huizinga, René EM Toes, Annemie JM Schuerwegh Arthritis Research & Therapy 2011, 13:R150 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects David A Rice, Peter J McNair, Gwyn N Lewis Arthritis Research & Therapy 2011, 13:R151 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article A validity-driven approach to the understanding of the personal and societal burden of low back pain: development of a conceptual and measurement model Rachelle Buchbinder, Roy Batterham, Gerald Elsworth, Clermont E Dionne, Emma Irvin, Richard H Osborne Arthritis Research & Therapy 2011, 13:R152 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Texture analysis of cartilage T₂maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T₂compared to normal controls - data from the osteoarthritis initiative Gabby B Joseph, Thomas Baum, Julio Carballido-Gamio, Lorenzo Nardo, Warapat Virayavanich, Hamza Alizai, John A Lynch, Charles E McCulloch, Sharmila Majumdar, Thomas M Link Arthritis Research & Therapy 2011, 13:R153 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis Toko Hashimoto, Shinsuke Yasuda, Hideyuki Koide, Hiroshi Kataoka, Tetsuya Horita, Tatsuya Atsumi, Takao Koike Arthritis Research & Therapy 2011, 13:R154 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis Jeffrey R Curtis, John W Baddley, Shuo Yang, Nivedita Patkar, Lang Chen, Elizabeth Delzell, Ted R Mikuls, Kenneth G Saag, Jasvinder Singh, Monika Safford, Grant W Cannon Arthritis Research & Therapy 2011, 13:R155 (20 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study Mandana Nikpour, Murray B Urowitz, Dominique Ibanez, Paula J Harvey, Dafna D Gladman Arthritis Research & Therapy 2011, 13:R156 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus Sebastian Dolff, Wayel H Abdulahad, Johanna Westra, Berber Doornbos-van der Meer, Pieter C Limburg, Cees GM Kallenberg, Marc Bijl Arthritis Research & Therapy 2011, 13:R157 (29 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis Kayoko Kaneko, Yoshishige Miyabe, Aiko Takayasu, Shin Fukuda, Chie Miyabe, Masashi Ebisawa, Waka Yokoyama, Kaori Watanabe, Toshio Imai, Kenzo Muramoto, Yuya Terashima, Takahiko Sugihara, Kouji Matsushima, Nobuyuki Miyasaka, Toshihiro Nanki Arthritis Research & Therapy 2011, 13:R158 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study Hoda Mirjafari, Tracey M Farragher, Suzanne MM Verstappen, Allen Yates, Diane Bunn, Tarnya Marshall, Mark Lunt, Deborah PM Symmons, Ian N Bruce Arthritis Research & Therapy 2011, 13:R159 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients Pieter WA Meyer, Bridget Hodkinson, Mahmood Ally, Eustasius Musenge, Ahmed A Wadee, Heidi Fickl, Mohammed Tikly, Ronald Anderson Arthritis Research & Therapy 2011, 13:R160 (6 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade Luke L Gompels, Nasser M Malik, Leigh Madden, Pei Jin, Marc Feldmann, H Michael Shepard, Ewa M Paleolog Arthritis Research & Therapy 2011, 13:R161 (7 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice Ao-Ho Hsieh, Yí-Jyun Jhou, Chung-Ting Liang, Mingi Chang, Shih-Lien Wang Arthritis Research & Therapy 2011, 13:R162 (11 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice Facundo Las Heras, Ralph S DaCosta, Kenneth PH Pritzker, Nigil Haroon, George Netchev, Hing Wo Tsui, Basil Chiu, W Mark Erwin, Florence WL Tsui, Robert D Inman Arthritis Research & Therapy 2011, 13:R163 (12 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Bone destruction by receptor activator of nuclear factor κB ligand-expressing T cells in chronic gouty arthritis Sung-Ji Lee, Kwang-Il Nam, Hye-Mi Jin, Young-Nan Cho, Song-Eun Lee, Tae-Jong Kim, Shin-Seok Lee, Seung-Jung Kee, Keun-Bae Lee, Nacksung Kim, Yong-Wook Park Arthritis Research & Therapy 2011, 13:R164 (13 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain Jae-Sung Kim, Jeffrey S Kroin, Xin Li, Howard S An, Asokumar Buvanendran, Dongyao Yan, Kenneth J Tuman, Andre J van Wijnen, Di Chen, Hee-Jeong Im Arthritis Research & Therapy 2011, 13:R165 (13 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore, Carlo Chizzolini Arthritis Research & Therapy 2011, 13:R166 (13 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article A five-year prospective study of fatigue in primary Sjögren's syndrome Karstein Haldorsen, Ingvar Bjelland, Anne Bolstad, Roland Jonsson, Johan Brun Arthritis Research & Therapy 2011, 13:R167 (13 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.
	Research article Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project Leigh F Callahan, Rebecca J Cleveland, Jack Shreffler, Todd A Schwartz, Britta Schoster, Randy Randolph, Jordan B Renner, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R169 (19 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low levels of educational attainment and living in a community with a high poverty rate are independently associated with knee osteoarthritis in a rural community in the south-eastern United States.
	Research article Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome Keiko Yoshimoto, Maiko Tanaka, Masako Kojima, Yumiko Setoyama, Hideto Kameda, Katsuya Suzuki, Kensei Tsuzaka, Yoko Ogawa, Kazuo Tsubota, Tohru Abe, Tsutomu Takeuchi Arthritis Research & Therapy 2011, 13:R170 (21 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article An organ culture system to model early degenerative changes of the intervertebral disc Ravi K Ponnappan, Dessislava Z Markova, Paul JD Antonio, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert, Makarand V Risbud Arthritis Research & Therapy 2011, 13:R171 (21 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn, Michael Sticherling, Percy Lehmann, Rudolf Stadler, Eckhard Schulze-Lohoff, Cornelia Seitz, Ivan Foeldvari, Thomas Krieg, Ekkehard Genth, Nicolas Hunzelmann Arthritis Research & Therapy 2011, 13:R172 (21 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: a randomised controlled trial Marta Alda, Juan V Luciano, Eva Andrés, Antoni Serrano-Blanco, Baltasar Rodero, Yolanda del Hoyo, Miquel Roca, Sergio Moreno, Rosa Magallón, Javier García-Campayo Arthritis Research & Therapy 2011, 13:R173 (23 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cognitive behaviour therapy (CBT) should be included in standard treatment of fibromyalgia, as a clinical trial shows it improves outcomes including pain catastrophising, pain acceptance, function and quality of life.
	Research article The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study Jie Zhang, Elizabeth Delzell, Fenglong Xie, John W Baddley, Claire Spettell, Raechele M Mcmahan, Joaquim Fernandes, Lang Chen, Kevin Winthrop, Jeffrey R Curtis Arthritis Research & Therapy 2011, 13:R174 (24 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients Diana Carmona-Fernandes, Maria Santos, Inês Perpétuo, João Fonseca, Helena Canhão Arthritis Research & Therapy 2011, 13:R175 (25 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis Amanda E Nelson, Robert F DeVellis, Jordan B Renner, Todd A Schwartz, Philip G Conaghan, Virginia B Kraus, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R176 (25 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham, John C Davis Arthritis Research & Therapy 2011, 13:R177 (26 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab Hilde Hammer, Magne K Fagerhol, Tale Wien, Tore K Kvien Arthritis Research & Therapy 2011, 13:R178 (26 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands Kwi Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Ju, Kyung-Su Park, Dong-Il Sun, Joo Jhun, Hye Oh, Sung-Hwan Park, Ho-Youn Kim Arthritis Research & Therapy 2011, 13:R179 (26 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes? Diederik PC De Rooy, Annemiek Willemze, Bart Mertens, Tom WJ Huizinga, Annette HM Van der Helm-van Mil Arthritis Research & Therapy 2011, 13:R180 (27 October 2011) Abstract \| Full text \| PDF \| PubMed

	Volume 13 Issue 5
	Comment
	Editorial Characterization of a novel and spontaneous mouse model of inflammatory arthritis Salvatore Cuzzocrea Arthritis Research & Therapy 2011, 13:126 (16 September 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Fibroblast growth factor 2: good or bad guy in the joint? Tonia L Vincent Arthritis Research & Therapy 2011, 13:127 (30 September 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Bisphosphonates for osteoarthritis David A Walsh, Victoria Chapman Arthritis Research & Therapy 2011, 13:128 (30 September 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Use of administrative claims data for comparative effectiveness research of rheumatoid arthritis treatments Seo Kim, Daniel H Solomon Arthritis Research & Therapy 2011, 13:129 (7 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Declining needs for total joint replacements for rheumatoid arthritis Nasim A Khan, Tuulikki Sokka Arthritis Research & Therapy 2011, 13:130 (19 October 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Pus: the Rodney Dangerfield of immunology David S Pisetsky Arthritis Research & Therapy 2011, 13:131 (26 October 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis Xinhua Yu, Saleh M Ibrahim Arthritis Research & Therapy 2011, 13:132 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Dupuytren's: a systems biology disease Samrina Rehman, Royston Goodacre, Philip J Day, Ardeshir Bayat, Hans V Westerhoff Arthritis Research & Therapy 2011, 13:238 (12 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis Manon C Zweers, Tineke N de Boer, Joël van Roon, Johannes WJ Bijlsma, Floris PJG Lafeber, Simon C Mastbergen Arthritis Research & Therapy 2011, 13:239 (21 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Lupus nephritis: current update Ramesh Saxena, Tina Mahajan, Chandra Mohan Arthritis Research & Therapy 2011, 13:240 (28 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models Simanta Pathak, Chandra Mohan Arthritis Research & Therapy 2011, 13:241 (30 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Osteoimmunology and osteoporosis Piet Geusens, Willem F Lems Arthritis Research & Therapy 2011, 13:242 (30 September 2011) Abstract \| Full text \| PDF \| PubMed
	Review Mechanisms of B cell autoimmunity in SLE Thomas Dörner, Claudia Giesecke, Peter E Lipsky Arthritis Research & Therapy 2011, 13:243 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Integrins and their ligands in rheumatoid arthritis Torsten Lowin, Rainer H Straub Arthritis Research & Therapy 2011, 13:244 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus Travis Hughes, Amr H Sawalha Arthritis Research & Therapy 2011, 13:245 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research
	Research article Integrated safety in tocilizumab clinical trials Michael H Schiff, Joel M Kremer, Angelika Jahreis, Emma Vernon, John D Isaacs, Ronald F van Vollenhoven Arthritis Research & Therapy 2011, 13:R141 (1 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines Yihong CS Lu, Christopher H Evans, Alan J Grodzinsky Arthritis Research & Therapy 2011, 13:R142 (2 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short term treatment of damaged cartilage with glucocorticoids can reduce long term degenerative changes; results from this in vitro study may offer hope for prevention of osteoarthritis after joint injury.
	Research article The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge Hua Yu, Changwan Lu, Ming T Tan, Kamal D Moudgil Arthritis Research & Therapy 2011, 13:R143 (13 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Ossification process involving the human thoracic ligamentum flavum: role of transcription factors Kenzo Uchida, Takafumi Yayama, Hong-Xin Cai, Hideaki Nakajima, Daisuke Sugita, Alexander Guerrero, Shigeru Kobayashi, Ai Yoshida, Ke-Bing Chen, Hisatoshi Baba Arthritis Research & Therapy 2011, 13:R144 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs Manoj Ramachandran, Prim Achan, Donald M Salter, Dan L Bader, Tina T Chowdhury Arthritis Research & Therapy 2011, 13:R145 (13 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability Hiroto Mitsui, Tomoki Aoyama, Moritoshi Furu, Kinya Ito, Yonghui Jin, Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, Akio Nishiura, Takanobu Otsuka, Takashi Nakamura, Junya Toguchida Arthritis Research & Therapy 2011, 13:R146 (14 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Improved responsiveness and reduced sample size requirements of PROMIS physical function scales with item response theory James F Fries, Eswar Krishnan, Matthias Rose, Bharathi Lingala, Bonnie Bruce Arthritis Research & Therapy 2011, 13:R147 (14 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article A new category of autoinflammatory disease associated with NOD2 gene mutations Qingping Yao, Lan Zhou, Philip Cusumano, Nilanjana Bose, Melissa Piliang, Bijal Jayakar, Le-Chu Su, Bo Shen Arthritis Research & Therapy 2011, 13:R148 (14 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice Kaoru Yoshida, Akira Ochiai, Hiroaki Matsuno, Gabriel S Panayi, Valerie M Corrigall Arthritis Research & Therapy 2011, 13:R149 (14 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium Jolien Suurmond, Annemarie L Dorjée, Mariëtte R Boon, Edward F Knol, Tom WJ Huizinga, René EM Toes, Annemie JM Schuerwegh Arthritis Research & Therapy 2011, 13:R150 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects David A Rice, Peter J McNair, Gwyn N Lewis Arthritis Research & Therapy 2011, 13:R151 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article A validity-driven approach to the understanding of the personal and societal burden of low back pain: development of a conceptual and measurement model Rachelle Buchbinder, Roy Batterham, Gerald Elsworth, Clermont E Dionne, Emma Irvin, Richard H Osborne Arthritis Research & Therapy 2011, 13:R152 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Texture analysis of cartilage T₂maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T₂compared to normal controls - data from the osteoarthritis initiative Gabby B Joseph, Thomas Baum, Julio Carballido-Gamio, Lorenzo Nardo, Warapat Virayavanich, Hamza Alizai, John A Lynch, Charles E McCulloch, Sharmila Majumdar, Thomas M Link Arthritis Research & Therapy 2011, 13:R153 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis Toko Hashimoto, Shinsuke Yasuda, Hideyuki Koide, Hiroshi Kataoka, Tetsuya Horita, Tatsuya Atsumi, Takao Koike Arthritis Research & Therapy 2011, 13:R154 (20 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis Jeffrey R Curtis, John W Baddley, Shuo Yang, Nivedita Patkar, Lang Chen, Elizabeth Delzell, Ted R Mikuls, Kenneth G Saag, Jasvinder Singh, Monika Safford, Grant W Cannon Arthritis Research & Therapy 2011, 13:R155 (20 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study Mandana Nikpour, Murray B Urowitz, Dominique Ibanez, Paula J Harvey, Dafna D Gladman Arthritis Research & Therapy 2011, 13:R156 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus Sebastian Dolff, Wayel H Abdulahad, Johanna Westra, Berber Doornbos-van der Meer, Pieter C Limburg, Cees GM Kallenberg, Marc Bijl Arthritis Research & Therapy 2011, 13:R157 (29 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis Kayoko Kaneko, Yoshishige Miyabe, Aiko Takayasu, Shin Fukuda, Chie Miyabe, Masashi Ebisawa, Waka Yokoyama, Kaori Watanabe, Toshio Imai, Kenzo Muramoto, Yuya Terashima, Takahiko Sugihara, Kouji Matsushima, Nobuyuki Miyasaka, Toshihiro Nanki Arthritis Research & Therapy 2011, 13:R158 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study Hoda Mirjafari, Tracey M Farragher, Suzanne MM Verstappen, Allen Yates, Diane Bunn, Tarnya Marshall, Mark Lunt, Deborah PM Symmons, Ian N Bruce Arthritis Research & Therapy 2011, 13:R159 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
	Research article HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients Pieter WA Meyer, Bridget Hodkinson, Mahmood Ally, Eustasius Musenge, Ahmed A Wadee, Heidi Fickl, Mohammed Tikly, Ronald Anderson Arthritis Research & Therapy 2011, 13:R160 (6 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade Luke L Gompels, Nasser M Malik, Leigh Madden, Pei Jin, Marc Feldmann, H Michael Shepard, Ewa M Paleolog Arthritis Research & Therapy 2011, 13:R161 (7 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice Ao-Ho Hsieh, Yí-Jyun Jhou, Chung-Ting Liang, Mingi Chang, Shih-Lien Wang Arthritis Research & Therapy 2011, 13:R162 (11 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice Facundo Las Heras, Ralph S DaCosta, Kenneth PH Pritzker, Nigil Haroon, George Netchev, Hing Wo Tsui, Basil Chiu, W Mark Erwin, Florence WL Tsui, Robert D Inman Arthritis Research & Therapy 2011, 13:R163 (12 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Bone destruction by receptor activator of nuclear factor κB ligand-expressing T cells in chronic gouty arthritis Sung-Ji Lee, Kwang-Il Nam, Hye-Mi Jin, Young-Nan Cho, Song-Eun Lee, Tae-Jong Kim, Shin-Seok Lee, Seung-Jung Kee, Keun-Bae Lee, Nacksung Kim, Yong-Wook Park Arthritis Research & Therapy 2011, 13:R164 (13 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain Jae-Sung Kim, Jeffrey S Kroin, Xin Li, Howard S An, Asokumar Buvanendran, Dongyao Yan, Kenneth J Tuman, Andre J van Wijnen, Di Chen, Hee-Jeong Im Arthritis Research & Therapy 2011, 13:R165 (13 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore, Carlo Chizzolini Arthritis Research & Therapy 2011, 13:R166 (13 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article A five-year prospective study of fatigue in primary Sjögren's syndrome Karstein Haldorsen, Ingvar Bjelland, Anne Bolstad, Roland Jonsson, Johan Brun Arthritis Research & Therapy 2011, 13:R167 (13 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: prescribing patterns, patient-level determinants of use, and patient-reported side effects Christopher J Smith, Harlan Sayles, Ted R Mikuls, Kaleb Michaud Arthritis Research & Therapy 2011, 13:R168 (18 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although the drugs are generally well-tolerated, rheumatologists mostly prescribe minocycline or doxycycline in patients with long-standing rheumatoid arthritis (RA) where other treatments have failed, and not as a primary treatment option.
	Research article Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project Leigh F Callahan, Rebecca J Cleveland, Jack Shreffler, Todd A Schwartz, Britta Schoster, Randy Randolph, Jordan B Renner, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R169 (19 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low levels of educational attainment and living in a community with a high poverty rate are independently associated with knee osteoarthritis in a rural community in the south-eastern United States.
	Research article Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome Keiko Yoshimoto, Maiko Tanaka, Masako Kojima, Yumiko Setoyama, Hideto Kameda, Katsuya Suzuki, Kensei Tsuzaka, Yoko Ogawa, Kazuo Tsubota, Tohru Abe, Tsutomu Takeuchi Arthritis Research & Therapy 2011, 13:R170 (21 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article An organ culture system to model early degenerative changes of the intervertebral disc Ravi K Ponnappan, Dessislava Z Markova, Paul JD Antonio, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert, Makarand V Risbud Arthritis Research & Therapy 2011, 13:R171 (21 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn, Michael Sticherling, Percy Lehmann, Rudolf Stadler, Eckhard Schulze-Lohoff, Cornelia Seitz, Ivan Foeldvari, Thomas Krieg, Ekkehard Genth, Nicolas Hunzelmann Arthritis Research & Therapy 2011, 13:R172 (21 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: a randomised controlled trial Marta Alda, Juan V Luciano, Eva Andrés, Antoni Serrano-Blanco, Baltasar Rodero, Yolanda del Hoyo, Miquel Roca, Sergio Moreno, Rosa Magallón, Javier García-Campayo Arthritis Research & Therapy 2011, 13:R173 (23 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cognitive behaviour therapy (CBT) should be included in standard treatment of fibromyalgia, as a clinical trial shows it improves outcomes including pain catastrophising, pain acceptance, function and quality of life.
	Research article The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study Jie Zhang, Elizabeth Delzell, Fenglong Xie, John W Baddley, Claire Spettell, Raechele M Mcmahan, Joaquim Fernandes, Lang Chen, Kevin Winthrop, Jeffrey R Curtis Arthritis Research & Therapy 2011, 13:R174 (24 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients Diana Carmona-Fernandes, Maria Santos, Inês Perpétuo, João Fonseca, Helena Canhão Arthritis Research & Therapy 2011, 13:R175 (25 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis Amanda E Nelson, Robert F DeVellis, Jordan B Renner, Todd A Schwartz, Philip G Conaghan, Virginia B Kraus, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R176 (25 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham, John C Davis Arthritis Research & Therapy 2011, 13:R177 (26 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab Hilde Hammer, Magne K Fagerhol, Tale Wien, Tore K Kvien Arthritis Research & Therapy 2011, 13:R178 (26 October 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands Kwi Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Ju, Kyung-Su Park, Dong-Il Sun, Joo Jhun, Hye Oh, Sung-Hwan Park, Ho-Youn Kim Arthritis Research & Therapy 2011, 13:R179 (26 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes? Diederik PC De Rooy, Annemiek Willemze, Bart Mertens, Tom WJ Huizinga, Annette HM Van der Helm-van Mil Arthritis Research & Therapy 2011, 13:R180 (27 October 2011) Abstract \| Full text \| PDF \| PubMed

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