Table 2

Differences between RA patients with and without CV events according to ACP1 polymorphisms

Change

Genotype, no. (frequency)

Minor allele,

Allele test

SNP

1/2

Samples Set

N

1/1

1/2

2/2

no. (frequency)

P-adj*

OR (95% CI)*

rs10167992

C/T

RA with CV

215

171 (0.826)

35 (0.169)

1 (0.005)

37 (0.089)

0.321

0.72 (0.38 to 1.37)

RA without CV

965

768 (0.799)

168 (0.175)

13 (0.014)

194 (0.102)

rs11553742

C/T

RA with CV

221

200 (0.966)

21 (0.101)

0 (0.000)

21 (0.048)

0.012

2.62 (1.24 to 5.53)

RA without CV

1,015

932 (0.970)

78 (0.081)

3 (0.003)

84 (0.041)

rs7576247

A/G

RA with CV

207

112 (0.541)

76 (0.367)

18 (0.087)

112 (0.272)

0.203

0.76 (0.50 to 1.16)

RA without CV

961

498 (0.518)

388 (0.404)

75 (0.078)

538 (0.280)

rs3828329

C/T

RA with CV

221

88 (0.425)

103 (0.498)

28 (0.135)

641 (0.319)

0.079

1.38 (0.96 to 1.97)

RA without CV

1,015

482 (0.502)

403 (0.419)

119 (0.124)

159 (0.363)

CV, cardiovascular; RA, rheumatoid arthritis

* multiple regression adjusted by age at diagnosis of the disease, gender, shared epitope status and traditional CV risk factors, that is, hypertension, diabetes mellitus, dyslipidemia, obesity and smoking habit, as potential confounders.

Teruel et al. Arthritis Research & Therapy 2011 13:R116   doi:10.1186/ar3401