Additional file 4.

Figure S2. PCI-32765 potentially inhibits multiple pathways in the pathogenesis of rheumatoid arthritis. PCI-32765 inhibits B cell activation, and suppresses cytokine/chemokine production from monocytes, macrophages, and mast cells following immune-complex activation (modified from [49]). Art by Jacqueline Schaffer, M.A.M.S., medical illustrator, for Pharmacyclics Inc.

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Chang et al. Arthritis Research & Therapy 2011 13:R115   doi:10.1186/ar3400