Typhlocolitis in a subset of IIJ mice. H & E-stained tissue sections of paraffin-embedded (A) and (B) colon and (C) and (D) cecum from IIJ mice (total magnification, ×100). (A) and (C) Noninflamed tissue from a NAR, 98-day-old IIJ mouse and (B) and (D) inflamed tissue from its AR littermate. Images are representative of sections from seven mice (see Table 3 for details). (E) Effective treatment of diarrhea with antibiotic-containing mouse chow. Mice were started on mouse chow and checked weekly for signs of diarrhea. (F) Colon:body weight ratios (g:g) for three groups of IIJ mice: mice that had never had diarrhea, mice with active diarrhea and mice that used to have diarrhea but had been successfully treated with antibiotics.
Adipue et al. Arthritis Research & Therapy 2011 13:R114 doi:10.1186/ar3399