Table 1

Cytokine-targeting agents and their clinical trials in SLE

Cytokine target

Therapeutic agent

Stage of clinical trial

References


IL-6

Tocilizumab

Phase I

[24]

TNFα

Infliximab, etanercept

Phase I; phase II and III trials terminated prematurely

[53-55]

IFNα

Sifalimumab (MEDI-545), rontalizumab (rhuMab)

Phase I; phase II ongoing

[102,103]

BLyS

Belimumab

Phase III completed

[115-121]

A-623

Phase I; phase II suspended/restarted

[123]

LY2127399

Phase III planned

[125]

BLyS and APRIL

Atacicept

Phase II/III initiated

[122]


Jacob and Stohl Arthritis Research & Therapy 2011 13:228   doi:10.1186/ar3349