Inhibition of IL-1β induced cytokine expression in human OA chondrocytes by EGCG (a, b). Chondrocytes were pretreated for 2 h with EGCG (100 μM) and then stimulated or not stimulated with IL-1β (5 ng/ml) for 24 h. Values represent Mean ± SE of three different patients. # represents P < 0.05 Vs control; * P < 0.05 Vs IL-1β stimulated chondrocytes. EGCG, epigallocatechin-3-gallate; GCSF, granulocyte colony stimulating factor; GM-CSF, granulocyte-macrophages colony stimulating factor; IFN-γ, interferon-γ; IL, interleukin; LIF, leukemia inhibitory factor; MCSF, macrophages colony stimulating factor; MIF, macrophage migratory inhibitory factor; TNF, tumor necrosis factor.
Akhtar and Haqqi Arthritis Research & Therapy 2011 13:R93 doi:10.1186/ar3368