Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Open Access Highly Accessed Research article

Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes

Nahid Akhtar and Tariq M Haqqi*

Author Affiliations

Department of Medicine/Rheumatology, MetroHealth Medical Centre, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA

For all author emails, please log on.

Arthritis Research & Therapy 2011, 13:R93  doi:10.1186/ar3368


See related editorial by Katiyar and Raman, http://arthritis-research.com/content/13/4/121

Published: 17 June 2011

Additional files

Additional file 1:

Effect of EGCG on nitrite production by human OA chondrocytes stimulated with IL-1β. (a) Chondrocytes were pretreated with EGCG (100 μM) for 2 h then stimulated with IL-1β (5 ng/ml) for 24 h and the culture supernatant was used for providing the cytokine antibody array. Bar represents mean ± SD of three patients, # represents P < 0.05 Vs control; * P < 0.05 Vs IL-1β stimulated chondrocytes. (b-e) Represents cytokine-antibody arrays showing the effects of EGCG on the expression pattern of cytokines produced by human OA chondrocytes upon IL-1β-stimulation. For the array layout and identification of cytokines please see additional file 2.

Format: TIFF Size: 1.5MB Download file

Open Data

Additional file 2:

Comprehensive map of cytokines antibody array.

Format: DOC Size: 37KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

Primer sequences used to quantify gene expression with real-time PCR.

Format: DOC Size: 40KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data