Table 1

Patient demographics and mean doses of rituximab received by patients with various autoimmune diseases

Diagnosis

Patients, n (%)

Total observation time, patient-years

Mean (SD) rituximab dose, mg


Total

370

299

2,440 (1,295)

Arthritis (non-RA)/ankylosing spondylitis/psoriatic arthritis

6 (1.6)

3.8

2,333 (816)

Autoimmune haemolytic anaemia

3 (0.8)

1.6

2,233 (204)

Autoimmune thrombocytopenia

10 (2.7)

6.5

2,602 (1,047)

Glomerulonephritis

9 (2.4)

7.0

2,150 (1,660)

Cryoglobulinaemic vasculitis

5 (1.4)

4.1

2,576 (971)

Wegener's granulomatosis/microscopic polyangiitis

58 (15.7)

61.4

3,008 (1,524)

Multiple sclerosis/neuromyelitis optica

56 (15.1)

48.3

2,679 (1,252)

Myasthenia gravis

5 (1.4)

2.7

1,890 (1,107)

Pemphigus

37 (10.0)

22.7

1,755 (1,163)

Sjögren's syndrome

6 (1.6)

4.3

2,271 (995)

Polydermatomyositis

26 (7.0)

23.4

2,634 (1,810)

Systemic lupus erythematosus

85 (23.0)

66.8

2,331 (1,033)

Vasculitis

13 (3.5)

9.5

2,277 (1,168)

Overlap syndromes: mixed connective tissue disease

19 (5.1)

16.3

2,550 (1,031)

Othersa

32 (8.6)

20.8

2,079 (1,224)


RA, rheumatoid arthritis; SD, standard deviation.

aOther autoimmune diseases included: Felty syndrome (n = 1); antiphospholipid syndrome (n = 1); chronic inflammatory demyelinating polyneuropathy (CIDP) (n = 3); anti-myelin associated glycoprotein associated with CIDP (n = 1); anti-Scl70-positive systemic sclerosis with myositis (n = 1); thrombotic thrombocytopenic purpura (n = 2); epidermolysis bullosa acquisita (n = 3); bullous pemphigoid (n = 1); mucous membrane pemphigoid (n = 1); uveitis (n = 1); Behçet disease (n = 1); systemic sclerosis (n = 1); systemic sclerosis with CREST syndrome (n = 1); diffuse cutaneous sclerosis (n = 1); common variable immunodeficiency (n = 1); Castleman's disease (n = 1); human immunodeficiency virus and myopathy (n = 1); Still's disease (n = 1); Crohn's disease (n = 1); Lambert-Eaton myasthenic syndrome (n = 1); autoimmune neuropathy (n = 1); stiff-person syndrome (n = 1); unspecified vasculitis (n = 1); anti-Hu positive encephalopathy of the brain stem (n = 1); acquired factor VIII haemophilia (n = 1); sarcoidosis (n = 1); diagnosis not specified (n = 1).

Tony et al. Arthritis Research & Therapy 2011 13:R75   doi:10.1186/ar3337

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