Table 2

Histomorphometric results for each mice group

Normal control group

Sham-OVX group

OVX group


OVX + Vehicle

OVX+E

PE (-)

PE (+)

PE (-)

PE (+)

PE (-)

PE (+)

PE (-)

PE (+)

SSA (mm2)

0.036 ± 0.008

(0.008 to .076)

0.10 ± 0.04

(0.05 to 0.33)

0.034 ± 0.007

(0.008 to 0.07)

0.093 ± 0.03

(0.05 to 0.34)

0.026 ± 0.01

(0.006 to 0.1)

0.09 ± 0.04

(0.01 to 0.35)

0.038 ± 0.01

(0.01 to 0.11)

0.20 ± 0.05

(0.07 to 0.46)

BT/TT

60 ± 4.7%

(42% to 80%)

48 ± 5.3%

(23% to 73%)

62 ± 4.6%

(49% to 80%)

45 ± 4%

(23% to 56%)

55 ± 5.2%

(35% to 73%)

49 ± 4.9%

(26% to 65%)

54 ± 5.5%

(31% to 73%)

37 ± 5.1%

(17% to 55%)

Δ(BT/TT)

-12 ± 5.3%

(-37% to 12%)

-16 ± 4.5%

(-39% to 5%)

-6.7 ± 4.9%

(-30% to 9%)

-17 ± 5%

(-37% to 1.2%)

Oc Nb

0.31 ± 0.3

(0 to 2)

2.2 ± 0.7

(0 to 5)

0.42 ± 0.3

(0 to 2)

2.5 ± 0.7

(0 to 5)

0.65 ± 0.4

(0 to 3)

0.7 ± 0.5

(0 to 4)

0.27 ± 0.2

(0 to 1)

2.1 ± 0.8

(0 to 6)


Values are expressed as mean ± standard error of the mean (extremes). BT, bone thickness; E, oestrogen; Oc Nb, osteoclast number; OVX, ovariectomy; PE, polyethylene; PE(-), sham-implanted; PE(+), PE-implanted; SSA, sagittal suture area; TT, tissue thickness.

Nich et al. Arthritis Research & Therapy 2011 13:R100   doi:10.1186/ar3381

Open Data