Effect of polyethylene particles on calvariae, as assessed by histology. Representative stained calvarial histology (Stevenel Blue, picrofuschine) is presented at ×20 original magnification (n = 7 per group). Polyethylene particles induced osteolysis, characterized by a consistent decrease in calvarial bone thickness and an inflammatory response (arrowheads) in normal controls (NC), sham-ovariectomized (OVX) mice and OVX mice supplemented with oestrogen (E), while it was moderate in OVX mice. PE(-): sham-implanted; PE(+): PE-implanted.
Nich et al. Arthritis Research & Therapy 2011 13:R100 doi:10.1186/ar3381