Effect of polyethylene particles on bone volume (BV), as assessed by longitudinal 3D micro-CT. Bone volume consistently decreased in all mice groups. However, bone loss was significantly lower in ovariectomized (OVX) mice as compared to normal controls (NC), sham-OVX mice and OVX animals supplemented with oestrogen (E). Bone volume was quantified using CTAn software. The data are presented as means ± standard error of the mean (a indicates P < 0.005; b indicates P < 0.05, compared to internal control, using Student's t-test).
Nich et al. Arthritis Research & Therapy 2011 13:R100 doi:10.1186/ar3381