Figure 2.

Effect of polyethylene particles on calvariae, as assessed by longitudinal 3D micro-CT. Representative reconstructed images of the calvarial volume of interest (VOI), two weeks after sham-implantation (PE(-)) or PE particles implantation (PE(+)) in different mice groups are shown (n = 7 per group). Of note is the consistent extent of bone resorption area following particles implantation in normal controls (NC), sham ovariectomized (OVX) mice and OVX animals supplemented with oestrogen (E), while bone resorption area appears limited in OVX animals implanted with particles.