Negative regulation of NF-κB and its involvement in rheumatoid arthritis
1 Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium
2 Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium
Arthritis Research & Therapy 2011, 13:221 doi:10.1186/ar3324Published: 31 May 2011
The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.