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Review

Negative regulation of NF-κB and its involvement in rheumatoid arthritis

Geert van Loo12 and Rudi Beyaert12

Author Affiliations

1 Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium

2 Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium

Arthritis Research & Therapy 2011, 13:221  doi:10.1186/ar3324

Published: 31 May 2011

Abstract

The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.