Bone remodeling. Bone remodeling begins when osteoclasts resorb bone mineral and matrix. Mononuclear cells prepare the resorbed surface for osteoblasts, which generate newly synthesized matrix as they differentiate. Matrix mineralization and the differentiation of some osteoblasts into osteocytes completes the remodeling cycle.
Kapinas and Delany Arthritis Research & Therapy 2011 13:220 doi:10.1186/ar3325