Table 3

Extrinsic factor-induced models of Sjögren's syndrome

Strain

Extrinsic factor

SS-like disease manifestations

Remarks

Reference

BALB/c

Ro amino acids 480 to 494

SG infl., ↓ SG function, anti-Ro and anti-La

Low disease penetrance rate

[136]

Ro amino acids 274 to 290

SG infl., ↓ SG function, anti-Ro and anti-La

Low disease penetrance rate

[136]

C57BL/6-Rag1^-/-

Six peptides from M3R

SG and LG infl., ↓ SG function

Splenocytes from vaccinated M3r^-/- mice

[140]

PL/J

CAII

SG infl.

Inflammatory lesions in multiple organs

[142]

C57BL/6-gld//gld

MCMV

SG infl., anti-Ro and anti-La

Incomplete clearance of the MCMV

[144]

Selection of murine strains in which Sjögren's syndrome (SS)-like disease manifestations develop after the administration of specific extrinsic factors. ↑, increased; ↓, decreased; CAII, carbonic anhydrase II; infl., inflammation; LG, lacrimal gland; M3R, muscarinic acetylcholine type-3 receptor; MCMV, murine cytomegalovirus; SG, salivary gland.

Delaleu et al. Arthritis Research & Therapy 2011 13:217   doi:10.1186/ar3313