Table 9

Changes in the expression of matrix proteins, their receptors, and integrins

rhOP-1 vs Cntr

OP-1AS vs Cntr

fold change

fold change

Accession no.

Matrix proteins

Collagen IV-α3

1.82↓

1.54↓

[GenBank:NM_000091]

Laminin-β1

1.65↓

3.38↓

[GenBank:NM_002291]

Chondroitin sulfate PG6 (bamacan)

1.60↓

1.52↑

[GenBank:NM_005445]

Versican (chondroitin sulfate PG2)

2.98↓

[GenBank:NM_004385]

Collagen I-α1

2.63↓

[GenBank:NM_000088]

Collagen XIV-α1

2.59↓

[GenBank:NM_021110]

Collagen I-α2

2.57↓

[GenBank:NM_000089]

Cartilage associated protein

2.13↓

[GenBank:NM_006371]

Cadherin 11 (OB-cadherin (osteoblast))

2.03↓

[GenBank:NM_001797]

Collagen XVI-α1

2.00↓

[GenBank:NM_001856]

Dermatan Sulfate PG3

1.57↑

1.95↓

[GenBank:NM_004950]

Collagen V-α1

1.89↓

[GenBank:NM_000093]

Bone sialoprotein

1.83↓

[GenBank:NM_004967]

Collagen VIII-α2

1.73↓

[GenBank:NM_005202]

Collagen VI-α1

1.70↓

[GenBank:NM_001848]

Collagen IV-α1

1.70↓

[GenBank:NM_001845]

Collagen IV-α2

1.69↓

[GenBank:NM_001846]

Syndecan

1.58↑

1.67↓

[GenBank:NM_002997]

Collagen V-α2

1.65↓

[GenBank:NM_000393]

Osteonectin

1.51↓

[GenBank:NM_003118]

Cadherin 19

1.50↓

[GenBank:NM_021153]

Collagen IX-α3

1.59↑

[GenBank:NM_001853]

Cadherin

1.54↑

[GenBank:NM_001408]

COMP

1.52↑

[GenBank:NM_000095]

Collagen IV-α5

1.89↑

[GenBank:NM_000495]

Chondroitin sulfate PG4

1.64↑

[GenBank:NM_001897]

Matrix protein receptors

HAS2

1.78↓

[GenBank:NM_005328]

CD44

2.34↓

[GenBank:NM_000610]

Integrins

Integrin-α5

1.77↓

[GenBank:NM_002205]

Integrin-β4

1.64↓

[GenBank:AF011375]

Integrin-α6

2.34↓

[GenBank:NM_000210]

Integrin-β-like 1

2.07↓

[GenBank:NM_004791]

Integrin-β3

1.72↓

[GenBank:NM_000212]

Integrin-αE

1.70↓

[GenBank:NM_002208]

Chubinskaya et al. Arthritis Research & Therapy 2011 13:R55   doi:10.1186/ar3300