Table 8

Association between OP-1 and other growth factors including igf-1, insulin, and tyrosine-kinase signaling

rhOP-1 vs Cntr

OP-1AS vs Cntr

fold change

fold change

IGF-BP1

2.17↓

Nerve growth factor-β

1.93↓

VEGF-β

1.62↓

1.50↓

Endothelial cell growth factor 1 (platelet-derived)

1.56↓

VEGF

1.52↓

Capillary morphogenesis protein 1

1.52↓

FGF-7

2.87↓

FGF-R2

1.69↑

2.83↓

IGF-BP5

1.90↓

FGF-R3

1.87↑

1.80↓

IGF-1R

1.73↓

PDGF-Rα

1.62↑

1.70↓

PDGF-Rβ

1.68↓

IGF-BP7

1.58↓

IRS2 (insulin receptor substrate 2)

2.10↓

1.70↑

DPYSL2 (dihydropyrimidinase-like 2)

1.60↑

1.60↓

MET (hepatocyte growth factor receptor)

1.70↓

1.60↑

SPRY2: sprouty homolog 2 (Drosophila)

1.60↓

1.60↑

SORBS1: sorbin and SH3 domain containing 1

1.70↑

1.50↓

PIK3R1 (Phosphoinositide-3-kinase, regulatory subunit 1)

1.72↑

MAP2K2 (mitogen-activated protein kinase kinase 2)

1.61↑

PDE3B (phosphodiesterase 3B, cGMP-inhibited)

2.00↑

SOCS3 (suppressor of cytokine signaling 3)

1.79↑

Chubinskaya et al. Arthritis Research & Therapy 2011 13:R55   doi:10.1186/ar3300