Table 7

Changes in the expression of TGF-β/BMP family related genes, their receptors, and signaling regulators

rhOP-1 vs Cntr

rhOP-1AS vs Cntr

fold change

fold change

Accession no.

GDF-15

3.04↓

2.03↑

[GenBank:NM_004864]

BMP-2

2.67↓

[GenBank:NM_001200]

Inhibin-βa (activin A)

2.32↓

2.15↑

[GenBank:NM_002192]

BMP-2 inducible kinase

1.61↓

[GenBank:NM_017593]

Parathyroid hormone-like hormone

1.60↓

2.17↑

[GenBank:NM_002820]

ID2

2.32↓

[GenBank:NM_002166]

Notch 4

2.32↓

[GenBank:NM_004557]

MAD-6

2.05↓

[GenBank:NM_005585]

Gremlin

1.88↑

1.94↓

[GenBank:NM_013372]

GDF-10

1.86↓

[GenBank:NM_004962]

ID4

1.82↑

1.84↓

[GenBank:NM_001546]

ID3

1.73↓

[GenBank:NM_002167]

MAD interacting protein

1.69↓

[GenBank:NM_004799]

MAD-4

1.67↓

[GenBank:NM_005359]

Notch 1

1.65↓

[GenBank:NM_017617]

MAD-7

1.62↓

[GenBank:NM_005904]

TGF-α

1.54↓

Receptors

Frizzled homolog 10 (Drosophila)

1.57↓

[GenBank:NM_007197]

Activin-α RI

1.53↓

[GenBank:NM_001105]

Activin A-RIIB

2.42↓

[GenBank:NM_001106]

BMPR1A

1.83↓

[GenBank:NM_004329]

TGF-βRI

1.51↓

[GenBank:NM_004612]

TGF-βRIII

1.50↓

[GenBank:NM_003243]

TGF-β R2

1.58↑

[GenBank:NM_003242]

Activin A-RIB

1.53↑

[GenBank:NM_004302]

Bone formation

Osteomodulin

1.78↑

2.56↓

[GenBank:NM_005014]

Chubinskaya et al. Arthritis Research & Therapy 2011 13:R55   doi:10.1186/ar3300