Table 6

Changes in proteases and their inhibitors

rhOP-1 vs Cntr

rhOP-1AS vs Cntr

fold change

fold change

Accession no.


Bcl-2

2.45↓

[GenBank:NM_001191]

Caspase 4, apoptosis-related cysteine protease

2.11↓

1.59↓

[GenBank:NM_001225]

Programmed cell death 8 (apoptosis-inducing factor)

1.70↓

[GenBank:NM_004208]

Calpain 9

1.55↓

[GenBank:NM_006615]

Caspase 6

2.18↓

[GenBank:NM_001226]

Caspase 8

1.82↓

[GenBank:NM_001228]

Caspase 2

1.50↑

[GenBank:NM_001224]

MMPs and inhibitors

TIMP-3

2.06↓

[GenBank:NM_000362]

MMP-14

1.55↓

[GenBank:NM_004995]

MMP-2

2.31↓

[GenBank:NM_004530]

TIMP-4

1.69↓

[GenBank:NM_003256]

MMP-9

1.50↓

[GenBank:NM_004994]

ADAM and ADAMTS

ADAM-19

1.83↓

[GenBank:NM_023038]

ADAM-15

1.51↓

[GenBank:NM_003815]

ADAMTS-12

1.88↑

2.03↑

[GenBank:NM_030955]

ADAMTS-7

1.58↑

[GenBank:NM_014272]

ADAM-10

2.34↓

[GenBank:NM_001110]

ADAM-28

1.63↓

[GenBank:NM_014265]

ADAM-9

1.61↓

[GenBank:NM_003816]

ADAM-7

1.56↑

[GenBank:NM_003817]

Cathepsins

Cathepsin B

2.14↓

[GenBank:NM_001908]

Cathepsin C

1.75↓

[GenBank:NM_001814]

Cathepsin S

1.75↓

[GenBank:NM_004079]

Other proteases

Transglutaminase 2

2.10↓

[GenBank:NM_004613]

Plasminogen activator-urokinase

1.57↓

[GenBank:NM_002658]

Tissue Plasminogen Activator

1.56↑

[GenBank:NM_000930]


Chubinskaya et al. Arthritis Research & Therapy 2011 13:R55   doi:10.1186/ar3300

Open Data