Table 3

Changes in the mediators of IL-6 signaling pathway

rhOP-1 vs Cntr

OP-1AS vs Cntr

fold change

fold change

Accession no.


Genes from IL-6 signaling pathway

ELK-1

1.89↓

[GenBank:NM_005229]

IL-6

2.09↓

1.60↑

[GenBank:NM_000600]

IL-6R

1.81↓

[GenBank:NM_000565]

IL-6 signal transducer (oncostatin M receptor)

1.63↓

[GenBank:NM_002184]

STAT1

2.42↓

[GenBank:NM_007315]

NFκBIα

1.86↓

1.58↑

[GenBank:NM_020529]

Protein inhibitor of activated STAT3

1.84↓

[GenBank:NM_006099]

STAT6

1.53↓

[GenBank:NM_003153]

MAP 3 kinase 7

1.67↓

[GenBank:NM_003188]

MAPK 14

1.52↓

[GenBank:L35253]

MAPK1

1.55↓


Chubinskaya et al. Arthritis Research & Therapy 2011 13:R55   doi:10.1186/ar3300

Open Data