Effect of post-treatment on histopathology of joint. At the completion of the 14-day post-treatment study all arthritic knee joints were removed and prepared for histological evaluation. Knee sections were scored (0 to 8) for the degree of cellular infiltration, synovial hyperplasia, cartilage damage and bone erosions. Rats treated with the sPLA2I (5 mg/kg) and infliximab showed reduced median scores compared to controls, though no significance was obtained. Treatment with sPLA2I (10 mg/kg) and leflunomide exhibited significantly reduced histopathology scores (P < 0.05, Mann-Whitney U test). Each data point represents the specific score with the median shown.
Coulthard et al. Arthritis Research & Therapy 2011 13:R42 doi:10.1186/ar3278