Effect of post-treatment on body weight. Right knee joints of all sensitised rats were injected with antigen on Day 0, and the change in body weight from Day 0 recorded every 48 hours for 14 days. Treatment was commenced two days following arthritis induction. The panels show: (A) Body weight over time for all treatment groups. (B) Change in body weight from baseline values. Arthritis control rats lost weight after 14 days, while all treatment groups gained weight, except for prednisolone-treated rats which lost considerable weight. Each data point represents the mean ± SEM. (P < 0.01). Significant differences from sham-operated rats (#) and arthritis controls (*) are indicated (P < 0.01).
Coulthard et al. Arthritis Research & Therapy 2011 13:R42 doi:10.1186/ar3278