Effect of sPLA2I pre-treatment on histopathology of joint. At the completion of the 14-day pre-treatment study all arthritic knee joints were removed and prepared for histological evaluation. Knee sections were scored (0 to 8) for the degree of cellular infiltration, synovial hyperplasia, cartilage damage and bone erosions. Only rats orally treated with the sPLA2I at 5 mg/kg/day showed a significant reduction in histopathology scores. Each data point represents a specific score with the median shown. ** indicates significant difference (P < 0.01) between arthritis controls and treatment group using the Mann-Whitney U test.
Coulthard et al. Arthritis Research & Therapy 2011 13:R42 doi:10.1186/ar3278