Effect of sPLA2I pre-treatment on joint swelling and lameness. Right knee joints of all sensitised rats were injected with antigen on Day 0. Knee widths (A) and gait scores (B) were recorded for each rat over 14 days. Treatment was commenced two days prior to arthritis induction and daily throughout. (A) Both oral doses of the sPLA2I resulted in a significant reduction of knee swelling throughout the study period. (B) Both oral doses of the sPLA2I resulted in a significant reduction of gait scores at various time points over the study period. Each data point represents the mean ± SEM. Lines indicate the period of significance (P < 0.05) between arthritis control and (A) both treatment groups; (B) dotted line - sPLA2I (5 mg/kg); solid line - sPLA2I (1 mg/kg).
Coulthard et al. Arthritis Research & Therapy 2011 13:R42 doi:10.1186/ar3278