Expression of Type I IFN signature genes in the three study groups. A stepwise pattern of increase is observed for IFITM3, MX1 and IFIT3. The genes IFI44L and IFI27 show increases that are relatively specific for SLE. Other IFN genes without elevation in the high ANA HC group shown with black symbols are: IFI6, HES4, ISG15, OAS1, IFIT3, HERC5, EIF2AK2.
Li et al. Arthritis Research & Therapy 2011 13:R38 doi:10.1186/ar3271