Table 4

Adjusted odds ratios and 95% confidence intervals for associations between ln Pb in quartiles and knee outcomes (joint-based analysis)a

Knee rOA

Knee sxOA


Knee outcomesb

ln Pb quartilesc

aORd

95% CI

ln Pb quartilesc

aORd

95% CI


Q2

1.09

0.81 to 1.48

Q2

1.10

0.77 to 1.56

Presence

Q3

1.18

0.89 to 1.58

Q3

1.16

0.83 to 1.62

Q4

1.27

0.93 to 1.74

Q4

1.24

0.86 to 1.79

Q2

1.07

0.80 to 1.43

Q2

1.06

0.75 to 1.51

Severitye

Q3

1.25

0.95 to 1.65

Q3

1.16

0.83 to 1.62

Q4

1.34

0.99 to 1.81

Q4

1.23

0.85 to 1.77


aaOR, adjusted odds ratio; CI, confidence interval; ln Pb, natural log-transformed lead; rOA, radiographic osteoarthritis; sxOA, symptomatic osteoarthritis; Q, quartile; breference category is no rOA for rOA outcomes, no sxOA for sxOA presence and rOA with no symptoms for sxOA severity outcomes; cmean Pb (±SD) in micrograms per deciliter level by quartile: Q1 (reference), 0.94 (±0.20); Q2, 1.5 (±0.15); Q3, 2.13 (±0.24); Q4, 4.92 (±3.93); dadjusted for age, sex, race and ethnicity, BMI, current smoking and current drinking; eproportional odds assumption met; a common OR describes the relationship between mild, moderate or severe compared to none, or between moderate or severe compared to mild or none.

Nelson et al. Arthritis Research & Therapy 2011 13:R37   doi:10.1186/ar3270

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