Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Review

Osteoarthritis subpopulations and implications for clinical trial design

Sita MA Bierma-Zeinstra12* and Arianne P Verhagen13

Author Affiliations

1 Department of General Practice, University Medical Centre Erasmus MC, 3000 CA Rotterdam, The Netherlands

2 Department of Orthopedics, University Medical Centre Erasmus MC, 3000 CA Rotterdam, The Netherlands

3 Avans University of Applied Sciences, School of Health, 4800 RA Breda, The Netherlands

For all author emails, please log on.

Arthritis Research & Therapy 2011, 13:213  doi:10.1186/ar3299

Published: 5 April 2011

Abstract

Treatment guidelines for osteoarthritis have stressed the need for research on clinical predictors of response to different treatments. However, identifying such clinical predictors of response is less easy than it seems, and there is not a given classification of osteoarthritis subpopulations. This review article highlights the key methodical issues when analyzing and designing clinical studies to detect important subgroups with respect to treatment effect. In addition, we discuss the main osteoarthritis subpopulations and give examples of how specific treatment effects in these subpopulations have been assessed.