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Highly Accessed Review

Novel autoantibodies and clinical phenotypes in adult and juvenile myositis

Zoe E Betteridge*, Harsha Gunawardena and Neil J McHugh

Author affiliations

Royal National Hospital for Rheumatic Diseases, NHS Foundation Trust, Upper Borough Walls, Bath, Somerset, BA1 1RL, UK

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Citation and License

Arthritis Research & Therapy 2011, 13:209  doi:10.1186/ar3275

Published: 18 March 2011

Abstract

Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositisspecific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the clinical associations of the myositisspecific autoantibodies, with particular attention to the recently identified and characterized novel myositis autoantibodies: p155/140, p140 (MJ), CADM-140 (MDA5), SAE, and 200/100.